Veterinary Anesthesia & Analgesia Support Group
Practical Information for the Compassionate Veterinary Practitioner
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    F Drugs
    Alphabetical Drug Summaries
    Dr. Bob Stein


a)      Classification

i)        A pure mu agonist

b)      General Information

i)        Duration of effect is 30 to 45 minutes

c)      Advantages/Recommended use

i)        Short-term analgesia

(1)   Excellent as an intra-operative “top up” analgesic

ii)       Induction agent when combined with a benzodiazepine

iii)     CRI analgesic use

d)      Cautionary Information

i)        May see panting and muscle rigidity

e)      Dosage Information

i)        Induction

(1)   See Diazepam & an Opioid section under Induction protocols for details

ii)       Analgesia

(1)   Bolus – 0.002 mg/kg (0.001 mg/lb)

(2)   CRI – 0.001 to 0.004 mg/kg/hr (0.005 to 0.002 mg/lb/hr)

(3)   Duragesic patch – based upon weight



Fentanyl Content

Small Dogs ** (<5kg) & Cats

25 mcg/hr

2.5 mg

Dogs: 5-10 kg  

25 mcg/hr

2.5 mg

Dogs: 10-20 kg

50 mcg/hr

5 mg

Dogs: 20-30 kg

75 mcg/hr

7.5 mg

Dogs: >30 kg   

2 x 50 mcg/hr

10 mg

(a)    Small dogs and cats, use the 25 mcg/hr patch but only expose ½ of the patch

(b)    For even smaller cats consider exposing ¼ of the patch

(c)    Never cut the patch

(d)    Clip hair as closely as possible at planned patch site without irritating the skin. Gently wipe area once or twice with slightly dampened gauze to remove loose hair. Let area dry. Warm patch to body temperature. Remove backing and apply patch to skin. Hold firmly against skin with hand for 2 full minutes. White tape and Kling gauze are used to cover and support the patch when possible.

(e)   For dogs greater than 30 kg, two 50 mcg patches will likely provide better drug delivery than one 100 mcg patch.

f)       Cost

i)        Low per IV use

ii)       High per patch







a)      Classification

i)        Benzodiazepine antagonist

b)      General Information

i)        Reversal agent for diazepam and midazolam

c)      Advantages/Recommended use

i)        To reverse any undesirable effects resulting from diazepam or midazolam use

d)      Cautionary Information

i)        None

e)      Dosage Information

i)        Dogs – 0.02 to 0.1 mg/kg (0.01 to 0.05 mg/lb) IV

ii)       Cats – 0.02 to 0.1 mg/kg (0.01 to 0.05 mg/lb) IV

f)       Cost

i)        Very high

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Last modified: February 22, 2011 .